منابع مشابه
Myocardial Opioid Receptors in Conditioning and Cytoprotection
Opioid compounds and G-protein coupled opioid receptors (ORs) have been studied widely in terms of central nervous system (CNS) actions relating to pain management and drug abuse. Opioids are also linked to induction of mammalian hibernation, a natural state of tolerance involving prolonged and orchestrated shifts in cellular metabolism, growth and stress resistance. It is not surprising then t...
متن کاملMyocardial conditioning: opportunities for clinical translation.
Myocardial conditioning is an endogenous cardioprotective phenomenon that profoundly limits infarct size in experimental models. The current challenge is to translate this paradigm from the laboratory to the clinic. Accordingly, our goal in this review is to provide a critical summary of the progress toward, opportunities for, and caveats to, the successful clinical translation of postcondition...
متن کاملMyocardial conditioning techniques in off-pump coronary artery bypass grafting
Off-pump coronary artery bypass surgery by avoiding cardioplegic arrest seems to reduce the risk of ischemic myocardial injury. However, even short-term regional ischemic periods, hemodynamic instability and arrhythmias associated with the procedure can be responsible for myocardial damage. Conditioning, a potential cardio-protective tool during on-pump cardiac surgery, has hardly been investig...
متن کاملReducing myocardial infarct size by remote ischemic conditioning
Ischemic heart disease is the leading cause of death and morbidity in the world, and ST-segment elevation myocardial infarction (STEMI) remains associated with a significant mortality rate and complications noted at 1-year follow-up, despite prompt coronary reperfusion achieved with either thrombolysis or primary percutaneous coronary intervention (PPCI). It is therefore clear that novel cardio...
متن کاملMyocardial protection by pre- and post-anesthetic conditioning.
BACKGROUND AND OBJECTIVES Perioperative myocardial ischemia is commonly observed, and it can increase significantly postoperative morbidity and mortality. The cardioprotective properties of volatile anesthetics and opioids have been studied during several decades and currently constitute powerful tools in the management of patients with ischemic coronariopathy. The objective of this review was ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2013
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.113.300764